Meredith must save Thatcher’s life; Izzie empathizes with a tumor-riddled patient; annoyed with Cristina's competitive zeal, Mark tricks her into assisting on an odd surgery.
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When the hospital lab tech, Isaac, discovers he has an inoperable tumor wrapped around his spine, he turns to Derek for help; Derek challenges Richard’s authority.
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The parents of Arizona’s 10-year-old patient offer the hospital a generous donation, but Arizona finds herself in a conflict of interest when the patient's condition worsens; Cristina tests her boundaries with Owen.
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Mark, Demetri and Wedeck try to connect Janis' attack with a separate attack made on them; Olivia confronts Mark about his experience; Demetri and Gough track down a clue from Mark’s; Dylan goes missing from the hospital.
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