The GAINES TWINS, ROXANNE (Kathy Griffin) and ROLAND (Jeremy Piven), a brother and sister pair with uncanny mental powers, being transported in an armoured convoy when a well planned traffic accident allows them to escape. Well, almost. That is until SPIDER-MAN (Neil Patrick Harris) appears on the scene and battles the twins' mental abilities and overcomes their brain-blasts with his own superhuman willpower. Later that afternoon Peter Parker learns that PTERODAX, the crime trio comprised of former KGB agents led by SERGEI (James Marsters), has just sprung SILVER SABLE (VIRGINIA MADSEN) from prison. SPIDER-MAN's enemies seem to be popping up all over! SILVER SABLE allies with KRAVEN THE HUNTER (Michael Dorn) who has recently escaped from jail as well in order to seek out revenge on SPIDER-MAN. SPIDER-MAN runs into MARY JANE WATSON / MJ (Lisa Loeb) and delivers some surprising news.